Serum and salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans in orofacial granulomatosis and Crohn's disease
| Autor: | Mukesh Mistry, Jeremy D. Sanderson, N. W. Savage, K Barnard, Michael Escudier, Stephen Challacombe, Durdana Rahman, P. J. Shirlaw |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Immunoglobulin A
Adult Male Saliva Adolescent Immunology Saccharomyces cerevisiae Microbiology Streptococcus mutans Antigen stomatognathic system Crohn Disease Immunity Clinical Studies Candida albicans Immunology and Allergy Humans Parotid Gland Child Immunity Mucosal Antibodies Fungal Aged Granuloma biology Middle Aged biology.organism_classification Antibodies Bacterial Corpus albicans stomatognathic diseases Immunoglobulin G Humoral immunity Immunoglobulin A Secretory biology.protein Female Antibody Mouth Diseases Biomarkers |
| Popis: | SUMMARY Orofacial granulomatosis (OFG) is a condition of unknown aetiology with histological and, in some cases, clinical association with Crohn's disease (CD). However, the exact relationship between OFG and CD remains uncertain. The aim of this study was to determine whether OFG could be distinguished immunologically from CD by comparing non-specific and specific aspects of humoral immunity in serum, whole saliva and parotid saliva in three groups of patients: (a) OFG only (n = 14), (b) those with both oral and gut CD (OFG + CD) (n = 12) and (c) CD without oral involvement (n = 22) and in healthy controls (n = 29). Non-specific immunoglobulin (IgA, SigA, IgA subclasses and IgG) levels and antibodies to whole cells of Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans were assayed by enzyme-linked immunosorbent assay (ELISA) in serum, whole saliva and parotid saliva. Serum IgA and IgA1 and IgA2 subclasses were raised in all patient groups (P |
| Databáze: | OpenAIRE |
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