Diagnosis and treatment of renin-secreting tumors. Report of three cases
| Autor: | Alain Raynaud, T T Guyenne, J M Duclos, M A Dufloux, D. Baruch, F. Alhenc-Gelas, Pierre Corvol, J M Brisset, J. C. Gaux, Joël Ménard |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Plasma renin activity chemistry.chemical_compound Internal medicine Renin–angiotensin system Renin Internal Medicine Medicine Humans Aldosterone business.industry Captopril Juxtaglomerular apparatus Juxtaglomerular cell Middle Aged medicine.disease Angiotensin II Juxtaglomerular Apparatus Kidney Neoplasms medicine.anatomical_structure Endocrinology chemistry Female business Juxtaglomerular cell tumor medicine.drug |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 6(5) |
| ISSN: | 0194-911X |
| Popis: | During the past 10 years, we have found renin-secreting renal juxtaglomerular cell tumors in three hypertensive patients (two women, one man, aged 22, 69, and 21 years, respectively). The major chemical and biological findings revealed the association of severe hypertension with hypokalemia and increased plasma renin activity and plasma aldosterone. The diagnosis of such tumors is difficult, and two of the three patients were followed up for four and five years respectively before undergoing surgery. The pharmacological blockade of the renin system by various agents (beta-blockers, angiotensin II antagonists, and captopril) and its effects on blood pressure and plasma renin activity proved to be unreliable. Renal venous catheterization for renin measurements failed to provide adequate localization of the tumor. Direct radioimmunoassay, however, showed the total plasma renin to be markedly elevated. In addition, renal arteriography showed an avascular area corresponding to the renin-secreting tumor in each of the three patients. All three patients were cured of hypertension and hypokalemia by excision of the tumor. |
| Databáze: | OpenAIRE |
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