Salvage of recurrence after surgery and adjuvant therapy: A systematic review
| Autor: | Joseph Zenga, Jenny X. Chen, Susan Fowler, Mark A. Varvares, Peter M. Vila, Jennifer Gross, Patrik Pipkorn, Jeremy D. Richmon |
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| Rok vydání: | 2018 |
| Předmět: |
Reoperation
medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Quality of life Adjuvant therapy Humans Medicine Postoperative Period 030223 otorhinolaryngology Salvage Therapy Chemotherapy business.industry Head and neck cancer Chemoradiotherapy Adjuvant medicine.disease Head and neck squamous-cell carcinoma Surgery Radiation therapy Oropharyngeal Neoplasms Systematic review Otorhinolaryngology 030220 oncology & carcinogenesis Neoplasm Recurrence Local business Chemoradiotherapy |
| Zdroj: | American Journal of Otolaryngology. 39:223-227 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2018.01.009 |
| Popis: | Purpose To determine the oncologic and functional outcomes of patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma after initial management with surgery and adjuvant therapy. Data sources Ovid Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov . Review methods A structured search was performed of the literature to identify studies that included patients undergoing surgical salvage for local, regional, or locoregional recurrent head and neck squamous cell carcinoma without known distant metastases who had been treated with initial surgery and post-operative adjuvant radio- or chemoradiotherapy. Studies were excluded if they did not report at least 1-year survival estimates, included patients who underwent primary non-surgical management, or included those treated with non-surgical salvage therapies or supportive care alone. Results The search strategy yielded 3746 abstracts. After applying exclusion and inclusion criteria, 126 full-texts were reviewed and six studies were included with a total of 222 patients. All studies were retrospective in design and included diverse disease subsites and stages. Complications and functional outcomes were inconsistently reported. Five-year survival estimates ranged between 10% and 40% between studies. Conclusions Patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma after initial surgery and adjuvant therapy may have a particularly poor prognosis. Future studies are needed to determine functional and quality of life outcomes in this patient population and to identify specific prognostic factors for re-recurrence and survival. |
| Databáze: | OpenAIRE |
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