Copper-Catalyzed Cascade Substitution/Cyclization of N-Isocyanates: A Synthesis of 1-Aminobenzimidazolones

Autor:	Jing An, Howard Alper, Andre M. Beauchemin
Rok vydání:	2016
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Substitution (logic) 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Cascade reaction Cascade Polymer chemistry Copper catalyzed Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic letters. 18(14)
ISSN:	1523-7052
Popis:	A copper-catalyzed cascade reaction of in situ generated nitrogen-substituted isocyanates (N-isocyanates) and 2-iodoanilines has been developed. The cascade relies on the base-catalyzed substitution of masked N-isocyanates, followed by Cu(I)-catalyzed coupling to afford a variety of 1-aminobenzimidazolones in moderate to excellent yields. This is the first example of a transition-metal-catalyzed cascade reaction involving N-isocyanate intermediates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58861b389f81f34d5b730d61cdf00af7 https://pubmed.ncbi.nlm.nih.gov/27341005 Zobrazit plný text záznamu