Epidemiological surveillance of schistosomiasis outbreak in Corsica (France): Are animal reservoir hosts implicated in local transmission?

Autor: Ricardo Pérez-Sánchez, Olivier Rey, Jérôme Boissier, Bruno Polack, Sébastien Grech-Angelini, Yann Quilichini, Anne Rognon, Ana Oleaga, Stephen Mulero, Aimé Brunet, Isabelle Vallée, Pascal Boireau, Julien Kincaid-Smith, Jean-François Allienne
Přispěvatelé: Oleaga, Ana, Pérez Sánchez, Ricardo, Parasitology Laboratory, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA, CSIC), Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Groupement Technique Vétérinaire de Corse, Sciences pour l'environnement (SPE), Université Pascal Paoli (UPP)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD), Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire d'Alfort (ENVA)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP), Oleaga, Ana [0000-0002-8019-7354], Pérez Sánchez, Ricardo [0000-0001-8875-439X], Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
RC955-962
Disease Outbreaks
Mice
0302 clinical medicine
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Prevalence
Schistosomiasis
2. Zero hunger
Schistosoma haematobium
Mammals
biology
Transmission (medicine)
Goats
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
Eukaryota
Agriculture
Ruminants
Animal Models
3. Good health
Infectious Diseases
Experimental Organism Systems
Parasitic disease
Human parasite
Vertebrates
Schistosoma
Livestock
Female
France
Public aspects of medicine
RA1-1270
Research Article
030231 tropical medicine
Zoology
Rodentia
Research and Analysis Methods
Rodents
03 medical and health sciences
Model Organisms
Helminths
medicine
Parasitic Diseases
Disease Transmission
Infectious
Animals
Humans
Disease Reservoirs
Sheep
business.industry
Public Health
Environmental and Occupational Health
Organisms
Outbreak
Biology and Life Sciences
biology.organism_classification
medicine.disease
Invertebrates
Schistosoma Haematobium
Rats
030104 developmental biology
Amniotes
Animal Studies
Cattle
business
Zdroj: PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007543 (2019)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2019, 13 (6), pp.e0007543. ⟨10.1371/journal.pntd.0007543⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2019, 13 (6), pp.e0007543. ⟨10.1371/journal.pntd.0007543⟩
Plos Neglected Tropical Diseases (1935-2735) (Public Library of Science (PLoS)), 2019-06, Vol. 13, N. 6, P. e0007543 (15p.)
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1935-2735
1935-2727
Popis: 15 páginas, 3 figuras y 2 tablas.
Environmental and anthropogenic changes are expected to promote emergence and spread of pathogens worldwide. Since 2013, human urogenital schistosomiasis is established in Corsica island (France). Schistosomiasis is a parasitic disease affecting both humans and animals. The parasite involved in the Corsican outbreak is a hybrid form between Schistosoma haematobium, a human parasite, and Schistosoma bovis, a livestock parasite. S. bovis has been detected in Corsican livestock few decades ago raising the questions whether hybridization occurred in Corsica and if animals could behave as a reservoir for the recently established parasite lineage. The latter hypothesis has huge epidemiological outcomes since the emergence of a zoonotic lineage of schistosomes would be considerably harder to control and eradicate the disease locally and definitively needs to be verified. In this study we combined a sero-epidemiological survey on ruminants and a rodent trapping campaign to check whether schistosomes could shift on vertebrate hosts other than humans. A total of 3,519 domesticated animals (1,147 cattle; 671 goats and 1,701 sheep) from 160 farms established in 14 municipalities were sampled. From these 3,519 screened animals, 17 were found to be serologically positive but were ultimately considered as false positive after complementary analyses. Additionally, our 7-day extensive rodent trapping (i.e. 1,949 traps placed) resulted in the capture of a total of 34 rats (Rattus rattus) and 4 mice (Mus musculus). Despite the low number of rodents captured, molecular diagnostic tests showed that two of them have been found to be infected by schistosomes. Given the low abundance of rodents and the low parasitic prevalence and intensity among rodents, it is unlikely that neither rats nor ruminants play a significant role in the maintenance of schistosomiasis outbreak in Corsica. Finally, the most likely hypothesis is that local people initially infected in 2013 re-contaminated the river during subsequent summers, however we cannot definitively rule out the possibility of an animal species acting as reservoir host.
JB received a grant from the ANSES (Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail) (https://www.anses.fr/fr). This study is set within the framework of the "Laboratoire d’Excellence (LABEX)" TULIP (ANR-10-LABX-41).
Databáze: OpenAIRE
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