Suppressive role of miR-592 in breast cancer by repressing TGF-β2
| Autor: | Yunhe Yu, Xiaoxue Bai, Ye Du, Xiaofeng Liu, Wenli Hou, Lelian Song, Haipeng Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Breast Neoplasms Biology medicine.disease_cause Transforming Growth Factor beta1 Mice 03 medical and health sciences 0302 clinical medicine Breast cancer Cell Movement Cell Line Tumor Internal medicine medicine Animals Humans Neoplasm Invasiveness Lymph node Aged Cell Proliferation Oncogene Cell growth Cancer General Medicine Middle Aged Cell cycle medicine.disease Xenograft Model Antitumor Assays Molecular medicine Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Cancer research Female Carcinogenesis |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2017.6029 |
| Popis: | The function of miR-592 has been investigated in many types of cancer, however its roles in breast cancer remain unclear. We therefore investigated the biological function and underlying mechanism of miR-592 in breast cancer. In the present study, a marked downregulation of miR-592 was observed in breast cancer tissues and cell lines compared to the matched adjacent non-tumor tissues and normal breast cell line. Statistical analysis revealed that decreased miR-592 was negatively associated with advanced clinical stage, distant metastasis and lymph node metastases. Function analysis demonstrated that overexpression of miR-592 significantly inhibited cell proliferation, clone formation, migration and invasion in breast cancer cells in vitro, as well as suppressed tumor growth in vivo. Furthermore, transforming growth factor β-2 (TGFβ-2), a known oncogene, was identified as a direct target of miR-592, and its mRNA expression level was inversely correlated with the expression level of miR-592 in human breast cancer specimens. Restoration of TGFβ-2 expression rescued the inhibitory effect in breast cancer cells caused by miR-592. Collectively, these data suggest that miR-592 may exert it suppressive role in breast cancer, at least in part, by targeting TGFβ-2, and that miR-592 may be a novel target for breast cancer treatment. |
| Databáze: | OpenAIRE |
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