Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents

Autor: Oana Cristina Duta, Muhammad Saqib, Anton Ficai, Roxana Trusca, Denisa Ficai, Vladimir F. Pichugin, Natalia Beshchasna, Jörg Opitz, Oleg Kuzmin, Ecaterina Andronescu, Honorata Kraśkiewicz, Łukasz Wasyluk, Au Yeung Kwan Ho
Přispěvatelé: Publica
Rok vydání: 2019
Předmět:
Materials science
Surface Properties
biological assessment
chemistry.chemical_element
Bioengineering
02 engineering and technology
engineering.material
010402 general chemistry
Cardiovascular System
01 natural sciences
Biomaterials
Plasma
chemistry.chemical_compound
Adsorption
Coated Materials
Biocompatible
X-Ray Diffraction
Coating
Spectroscopy
Fourier Transform Infrared
Human Umbilical Vein Endothelial Cells
Humans
EDX and FTIR
Deposition (phase transition)
cardiovascular stent
Composite material
Electrodes
Titanium
magnetron sputtering
surface evaluation by SEM
titanium oxynitride coating
Electrochemical Techniques
electrochemical
Sputter deposition
Elements
021001 nanoscience & nanotechnology
protein adsorption
Titanium nitride
0104 chemical sciences
Corrosion
chemistry
Mechanics of Materials
Titanium dioxide
engineering
Stents
0210 nano-technology
in-vitro biocompatibility
static and dynamic exposure to simulated body fluids
Protein adsorption
Zdroj: Materials Science and Engineering: C. 99:405-416
ISSN: 0928-4931
DOI: 10.1016/j.msec.2019.01.131
Popis: Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.
Databáze: OpenAIRE
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