Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions

Autor:	Antoine Cortot, Mimouna Seddik, Benoit Wallaert, C. Duburque, R. Iacob, C. Fournier, J. Lelong, Jean-Frederic Colombel, Pierre Desreumaux
Rok vydání:	2006
Předmět:	Adult Hypersensitivity Immediate Male medicine.medical_specialty Anti-Inflammatory Agents Drug Administration Schedule Immune tolerance Drug Hypersensitivity Clinical Protocols Crohn Disease Gastrointestinal Agents medicine Humans Pharmacology (medical) In patient Infusions Intravenous Crohn's disease Hepatology business.industry Gastroenterology Complete remission Antibodies Monoclonal Middle Aged medicine.disease Infliximab Surgery Treatment Outcome Delayed hypersensitivity Significant response Female business Perfusion medicine.drug
Zdroj:	Alimentary pharmacologytherapeutics. 24(5)
ISSN:	0269-2813
Popis:	Summary Aim To appraise the tolerance and efficacy of an induction of tolerance protocol to infliximab permitting the re-administration of the drug to patients with Crohn's disease having had infusion reactions requiring suspension of treatment. Methods Fourteen patients were included in the induction of tolerance protocol. Each infusion of infliximab (5 mg/kg) was divided into 11 escalating 15 min increments over a 3-h time period. The induction of tolerance procedure was repeated for subsequent infusions. Results Ten patients (71.4%) received all the three infusions for the induction treatment. Nine (64.3%) had a significant response and six (48.8%) still benefited from infliximab infusions. Seven patients (50%) achieved a complete remission, after a mean of 2.5 (two to three) infusions. Four patients (28.6%) had no response and the protocol was stopped. Three patients (21.4%) experienced mild immediate hypersensitivity reactions, which were controlled, two patients (14.2%) experienced severe immediate hypersensitivity reactions, leading to interruption of the treatment and one patient developed a delayed hypersensitivity reaction. Conclusion Our induction of tolerance protocol allows some patients who have experienced severe or repetitive infusion reactions to infliximab to be safely retreated with the drug in a hospitalized setting, with a clinical response achieved in a majority of these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5883873cd16d9b26ba6fe70a88947c82 https://pubmed.ncbi.nlm.nih.gov/16918890 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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