Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites
| Autor: | David C. Jackson, Charles G. Gauci, AJ Read, Damien R. Drew, D.L Dadley-Moore, Marshall W. Lightowlers, David D. Heath, S.M Gauci, Conan Chow |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Swine
RNA Splicing Cattle Diseases Sheep Diseases Echinococcus multilocularis Host-Parasite Interactions Epitopes Antigen Echinococcosis parasitic diseases medicine Taeniasis Animals Echinococcus granulosus Genes Helminth Ovum Swine Diseases Vaccines Synthetic Sheep biology Taenia Reverse Transcriptase Polymerase Chain Reaction Oncosphere biology.organism_classification medicine.disease Virology Infectious Diseases Echinococcus Parasitology Antigens Helminth Cattle |
| Zdroj: | International journal for parasitology. 33(11) |
| ISSN: | 0020-7519 |
| Popis: | Highly effective recombinant vaccines have been developed against Taenia ovis infection in sheep, Taenia saginata infection in cattle, Taenia solium infection in pigs, Echinococcus granulosus and Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have been based on the identification and expression in Escherichia coli of antigens derived from the oncosphere life cycle stage, contained within the parasites' eggs. Investigation of the molecular aspects of these proteins and the genes encoding them have revealed a number of common features, including the presence of a predicted secretory signal sequence, and one or two copies of a fibronectin type III domain, each encoded by separate exons within the associated gene. Evidence has been obtained to confirm glycosylation of some of these antigens. Ongoing investigations will shed light on the biological roles played by the proteins within the parasites and the mechanism by which they make the parasites vulnerable to vaccine-induced immune responses. |
| Databáze: | OpenAIRE |
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