| Autor: |
Aaron W. P. Maxwell, Humberto G. Mendoza, Matthew J. Sellitti, Juan C. Camacho, Amy R. Deipolyi, Etay Ziv, Constantinos T. Sofocleous, Hooman Yarmohammadi, Majid Maybody, John L. Humm, Jazmin Schwartz, Krishna Juluru, Mark P. Dunphy, F. Edward Boas |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cardiovasc Intervent Radiol |
| Popis: |
PURPOSE: To determine how particle density affects dose distribution and outcomes after lobar radioembolization. METHODS: Matched pairs of patients, treated with glass versus resin microspheres, were selected by propensity score matching (114 patients), in this single-institution retrospective study. For each patient, tumor and liver particle density (particles/cm(3)) and dose (Gy) were determined. Tumor-to-normal ratio was measured on both (99m)Tc-MAA SPECT/CT and post-(90)Y bremsstrahlung SPECT/CT. Microdosimetry simulations were used to calculate 1(st) percentile dose, which is the dose in the cold spots between microspheres. Local progression-free survival (LPFS) and overall survival were analyzed. RESULTS: As more particles were delivered, doses on (90)Y SPECT/CT became more uniform throughout the treatment volume: tumor and liver doses became more similar (p=0.04), and microscopic cold spots between particles disappeared. For hypervascular tumors (tumor-to-normal ratio ≥ 2.6 on MAA scan), delivering fewer particles ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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