An Extremely Rapid Case of Pneumonitis with the Use of Nivolumab for Pancreatic Adenocarcinoma
| Autor: | Haijun Zhou, Sarah M. Talamantes, Amir Behdad, Al B. Benson, Maureen Sadim, Aparna Kalyan, R. Costa, Vahid Yaghmai, Ricardo Costa, Jason B. Kaplan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Cancer Case Report Disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 Unmet needs 03 medical and health sciences 0302 clinical medicine Oncology Respiratory failure 030220 oncology & carcinogenesis Internal medicine Pancreatic cancer medicine Adenocarcinoma 030212 general & internal medicine Nivolumab business Pneumonitis |
| Zdroj: | Case Reports in Oncological Medicine Case Reports in Oncological Medicine, Vol 2018 (2018) |
| ISSN: | 2090-6714 2090-6706 |
| Popis: | Pancreatic cancer is the fourth most common cancer death in the United States despite comprising a small percentage of the total number of cancer cases. The estimated 5-year overall survival (OS) for patients with distant metastatic disease is approximately 3%. New treatment options are an unmet need and remain an area of active investigation. A 53-year-old male with metastatic pancreatic cancer presented to the hospital with acute-on-chronic respiratory failure approximately 24 hours after receiving a novel therapeutic combination. Chest imaging showed marked changes as concerning for pneumonitis. Infectious workup was negative. The patient had initial clinical improvement after receiving initial intravenous steroids and oxygen support but eventually deteriorated later opting for supportive measures only. With infection ruled out, drug-induced pneumonitis was felt to be the likely cause of the radiologic and clinical changes. The rapidity of onset of symptoms is the aspect being highlighted in this case. |
| Databáze: | OpenAIRE |
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