Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men
| Autor: | Rebecca Yang, Johannes D. Veldhuis, Ferdinand Roelfsema |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Time Factors Adolescent Injections Subcutaneous Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Pulsatile flow 030209 endocrinology & metabolism Context (language use) Biochemistry Proinflammatory cytokine Young Adult 03 medical and health sciences Subcutaneous injection 0302 clinical medicine Endocrinology Double-Blind Method Internal medicine medicine Humans Prospective Studies Saline Aged Aged 80 and over Clinical Research Article Cross-Over Studies Secretory Pathway business.industry interleukin Biochemistry (medical) Age Factors Interleukin Middle Aged Crossover study Healthy Volunteers Growth hormone secretion cytokines 030104 developmental biology inflammation growth hormone Interleukin-2 business |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 106(10), 2855-2864. ENDOCRINE SOC J Clin Endocrinol Metab |
| Popis: | Context Interleukin-2 (IL-2), a proinflammatory cytokine, has been used to treat malignancies. Increased cortisol and adrenocorticotropin (ACTH) were noted, but growth hormone (GH) secretion was not investigated in detail. Objective We quantified GH secretion after a single subcutaneous injection of IL-2 in 17 young and 18 older healthy men in relation to dose, age, and body composition. Methods This was a placebo-controlled, blinded, prospectively randomized, crossover study. At 20:00 hours IL-2 (3 or 6 million units/m2) or saline was injected subcutaneously. Lights were off between 23:00 and 07:00 hours. Blood was sampled at 10-minute intervals for 24 hours. Outcome measures included convolution analysis of GH secretion. Results GH profiles were pulsatile under both experimental conditions and lower in older than young volunteers. Since the effect of IL-2 might be time limited, GH analyses were performed on the complete 24-hour series and the 6 hours after IL-2 administration. Total and pulsatile 24-hour GH secretion decreased nonsignificantly. Pulsatile secretion fell over the first 6 hours after IL-2 (P = .03), with visceral fat as a covariate (P = .003), but not age (P = .10). Plots of cumulative 2-hour bins of GH pulse mass showed a distinction by treatment and age groups: A temporary GH decrease of 32% and 28% occurred in the first 2-hour bins after midnight (P = .02 and .04) in young participants, whereas in older individuals no differences were present at any time point. Conclusion This study demonstrates that IL-2 temporarily diminishes GH secretion in young, but not older, men. |
| Databáze: | OpenAIRE |
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