Synthesis of Hafnium(IV) Polyaminoacetates
| Autor: | Konstantin Yu. Zhizhin, Alexey A. Lipengolts, N. A. Selivanov, Andrey P. Zhdanov, Evgeniy O. Bortnikov, Alexander Yu. Bykov, Alexandra T. Shulyak, N. T. Kuznetsov, A. S. Kubasov |
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| Rok vydání: | 2021 |
| Předmět: |
hafnium
Pharmaceutical Science chemistry.chemical_element Ethylenediamine 010402 general chemistry 01 natural sciences Chloride Article 030218 nuclear medicine & medical imaging Analytical Chemistry Coordination complex 03 medical and health sciences chemistry.chemical_compound QD241-441 0302 clinical medicine Bromide Drug Discovery medicine Physical and Theoretical Chemistry ligand effect chemistry.chemical_classification Low toxicity structure elucidation Organic Chemistry Nitrilotriacetic acid contrast agent 0104 chemical sciences Hafnium chemistry Chemistry (miscellaneous) coordination chemistry DTPA Molecular Medicine Single crystal complexonates Nuclear chemistry medicine.drug |
| Zdroj: | Molecules, Vol 26, Iss 3725, p 3725 (2021) Molecules Volume 26 Issue 12 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26123725 |
| Popis: | The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability. |
| Databáze: | OpenAIRE |
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