Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454
| Autor: | Rui Hua Jiao, Ren-Xiang Tan, Ping Cheng, Sheng Tao Bo, Hui Ming Ge, Zi Fei Xu, Li Yang |
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| Rok vydání: | 2017 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry 01 natural sciences Streptomyces Bacterial genetics chemistry.chemical_compound Polyketide Biosynthesis Drug Discovery Gene cluster Mayamycin Gene Pharmacology biology 010405 organic chemistry Computational Biology biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry chemistry Genes Bacterial Polyketides Antibacterial activity Polyketide Synthases |
| Zdroj: | The Journal of antibiotics. 71(6) |
| ISSN: | 1881-1469 |
| Popis: | Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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