Improved foot-and-mouth disease vaccine with O PanAsia-2 strain protect pigs against O/Jincheon/SKR/2014 originated from South Korea
| Autor: | Joo-Hyung Choi, Sung Ho Shin, Jong-Hyeon Park, Byounghan Kim, Su-Mi Kim, Hyundong Jo, Hye-Eun Jo, Min Ja Lee, Su-Hwa You, Mi-Kyeong Ko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Swine
030231 tropical medicine Biology Antibodies Viral Virus 03 medical and health sciences 0302 clinical medicine Immunogenicity Vaccine Immunity medicine Animals 030212 general & internal medicine Viral shedding Swine Diseases General Veterinary General Immunology and Microbiology Foot-and-mouth disease Public Health Environmental and Occupational Health Outbreak Viral Vaccines medicine.disease Virology Antibodies Neutralizing Vaccination Titer Infectious Diseases Immunization Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Molecular Medicine Cattle |
| Zdroj: | Vaccine. 38(5) |
| ISSN: | 1873-2518 |
| Popis: | Efforts are required to develop foot-and-mouth disease (FMD) vaccines in Asia that can respond to the type O outbreaks that have continued with the devastating damage since 2010. It is necessary to develop vaccine strains that can provide protection against the ME-SA topotype, which has tended to spread into neighboring areas, and the frequent SEA topotype outbreaks. To this end, this study aimed to develop a FMD vaccine utilizing O PanAsia-2 that is able to provide broad protection against ME-SA as the vaccine strain, with a focus on the O/Jincheon/SKR/2014 virus (SEA topotype), the outbreaks of which have persisted in spite of the enforcement of FMD vaccination. The virus neutralizing antibody (VN) titer to the ME-SA topotype (especially, Ind2001 lineage) virus in pigs was the highest, followed by SEA, while the VN titers to the Cathay and EURO-SA topotypes were similar. In the O/Jincheon/SKR/2014 virus challenge test, all pigs were protected against the virus, and almost no virus shedding was detected after the virus challenge. In the immunization test performed on cattle and pigs, antibodies with sufficient protective activity were produced in cattle two weeks after the first immunization, and pigs exhibited lower immunity compared to cattle. However, immunity was improved enough in pigs to provide protection against the virus challenge after the second immunization, with a significant increase in antibody production. |
| Databáze: | OpenAIRE |
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