Systemic plasma vascular endothelial growth factor levels as a marker for increased angiogenesis during the single ventricle surgical pathway
| Autor: | G. B. W. E. Bennink, Ali Dodge-Khatami, Narayanswami Sreeram, B. A. J. M. de Mol |
|---|---|
| Přispěvatelé: | Cardiothoracic Surgery |
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Angiogenesis Venous blood Hypoxia (medical) Vascular endothelial growth factor B Vascular endothelial growth factor chemistry.chemical_compound Vascular endothelial growth factor A medicine.anatomical_structure chemistry Vascular endothelial growth factor C Ventricle Internal medicine cardiovascular system Cardiology Medicine Surgery medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Interactive cardiovascular and thoracic surgery, 2(4), 458-461. Oxford University Press |
| ISSN: | 1569-9285 |
| Popis: | Cyanosis and the cavopulmonary anastomosis (CPA) are associated with pulmonary arterio-venous malformations (PAVMs) in single ventricle physiology. Vascular endothelial growth factor (VEGF) may be a marker of abnormal angiogenesis in this setting. Plasma VEGF levels were measured in 14 patients undergoing the surgical pathway leading to total cavopulmonary connection (TCPC). Venous blood samples were taken before and then months after CPA (n=6), and immediately before TCPC and 1 month thereafter (n=9). Corresponding arterial saturations were correlated with VEGF levels at each time frame. In six patients, pre-CPA plasma VEGF levels rose from a mean of 24.4-112.4 pg/ml (p |
| Databáze: | OpenAIRE |
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