Mechanism of delayed intracranial hypertension after cerebroventricular infusions in conscious rats
| Autor: | Bret A. Morrow, Michelle R. Holt, Vesna Starcevic, Lanny C. Keil, Walter B. Severs |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Time Factors Intracranial Pressure Balanced salt solution Ouabain Cerebral Ventricles Cerebrospinal fluid Animals Medicine Infusions Parenteral Molecular Biology Intracranial pressure business.industry General Neuroscience Rats Inbred Strains Rats Acetazolamide Anesthesia Neurology (clinical) Cerebrospinal fluid pressure business Artificial cerebrospinal fluid Perfusion Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 570:218-224 |
| ISSN: | 0006-8993 |
| Popis: | Prior studies showed that cerebroventricular infusions of artificial cerebrospinal fluid, 8 microliter/min for 10 min, followed by a 10 min rest and a 24 h infusion of 0.5 microliters/min, raised cerebrospinal fluid pressure (CSFp) of conscious, unrestrained rats after about 2 h. Here, we report that the 10 min infusion alone evoked a delayed, prolonged rise in CSFp. Pressure during the infusion itself rose and recovered quickly, as is usually reported. Pressure/volume tests, used to calculate resistance to outflow (Ro) and compliance (C), revealed that infusions increased Ro and decreased C, after a delay (P less than 0.05). The rise in CSFp after infusion was blocked by pretreatment with acetazolamide + ouabain (P less than 0.05), but the delayed changes in Ro and C were unaffected. We suggest that the 10 min infusion of a sterile, balanced salt solution has a primary effect that increases Ro; as CSF synthesis continues, C is exhausted and the delayed rise in CSFp ensues. This non-traumatic method of raising CSFp may be a useful method to study intracranial fluid dynamics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|