The Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene Is Not Associated with Training-Induced Changes in Body Composition: The HERITAGE Family Study
| Autor: | Christophe Garenc, Jack H. Wilmore, Tuomo Rankinen, Jacques Gagnon, James S. Skinner, D. C. Rao, Louis Pérusse, Arthur S. Leon, Claude Bouchard |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Black People Medicine (miscellaneous) Arginine Polymerase Chain Reaction White People Body Mass Index Endocrinology Gene Frequency Endurance training Polymorphism (computer science) Internal medicine Humans Medicine Allele Receptor Gene Polymorphism Genetic business.industry Gene Amplification Tryptophan Public Health Environmental and Occupational Health Genotype frequency Phenotype Adipose Tissue Receptors Adrenergic beta-3 Body Composition Physical Endurance Female Composition (visual arts) business Body mass index Food Science |
| Zdroj: | Obesity Research. 9:337-341 |
| ISSN: | 1071-7323 |
| Popis: | Objective: To investigate the association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and changes in body composition in response to endurance training. Research Methods and Procedures: Adult sedentary white and black subjects participating in the HERITAGE Family Study were measured before and after 20 weeks on endurance training for the body mass index, fat mass, percentage of body fat, fat-free mass, sum of eight skinfolds, and subcutaneous, visceral, and total abdominal fat areas. The association between the Trp64Arg polymorphism and the response phenotypes, computed as the difference between pre- and post-training values, was tested by analysis of covariance separately in men and women. The gene by race interaction term was also tested. Results: No race differences were observed for allelic and genotype frequencies. Training resulted in significant reduction of body fat in both men and women. No association of the Trp64Arg polymorphism was observed with training-induced changes for any of the body composition phenotypes in both men and women. Discussion: These results suggest that the Trp64Arg polymorphism of the β3-adrenergic receptor gene is not related to changes in body composition in response to exercise training. |
| Databáze: | OpenAIRE |
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