Metabolites from the leaf extract of Serjania yucatanensis with trypanocidal activity against Trypanosoma cruzi
| Autor: | Hernán Sagua-Franco, Glendy Polanco-Hernández, Manuel Jesús Chan-Bacab, Luis M. Peña-Rodríguez, Karlina García-Sosa, Fabiola Escalante-Erosa, Jorge González, Luis Osorio-Rodríguez |
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| Rok vydání: | 2011 |
| Předmět: |
Trypanosoma cruzi
Antiprotozoal Agents Biology Sesquiterpene chemistry.chemical_compound Inhibitory Concentration 50 Sapindaceae Triterpene Parasitic Sensitivity Tests Chlorocebus aethiops Bioassay Animals Vero Cells Lupeol chemistry.chemical_classification General Veterinary Traditional medicine Plant Extracts General Medicine Serjania yucatanensis biology.organism_classification Triterpenes Plant Leaves Infectious Diseases chemistry Phytochemical Biochemistry Insect Science Vero cell Parasitology Biological Assay Sesquiterpenes |
| Zdroj: | Parasitology research. 111(1) |
| ISSN: | 1432-1955 |
| Popis: | The bioassay-guided phytochemical investigation of the leaf extract of Serjania yucatanensis, a woody climbing plant endemic to the Yucatan peninsula, led to the identification of a mixture of a triterpene [lup-20(29)-en-3-one] and an oxygenated sesquiterpene (β-caryophyllene oxide), as that responsible for the originally detected trypanocidal activity in the organic crude extract. Results showed that the mixture of lup-20(29)-en-3-one and β-caryophyllene oxide is active against trypomastigotes of Trypanosoma cruzi (IC(50) =80.3 μg/mL) and inhibits the egress of trypomastigotes from infected Vero cells (when tested at 100 μg/mL) without being cytotoxic. |
| Databáze: | OpenAIRE |
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