Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers
| Autor: | Thomas H. Connor, Belinda C. Johnson, Bonnie Rogers, John C. Clark, Peter S.J. Lees, Melissa A. McDiarmid, Tracy Roth, D. Gayle DeBord, Marc Oliver, Jack R. Pretty, Edward F. Krieg, Christine A. Toennis, Carmen P. Escalante |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Gerontology Drug medicine.medical_specialty Cross-sectional study Health Personnel media_common.quotation_subject MEDLINE Antineoplastic Agents Pharmacy Occupational safety and health Occupational medicine Occupational Exposure Oncology Service Hospital Health care Humans Medicine Occupational Health media_common Academic Medical Centers business.industry Public Health Environmental and Occupational Health Hazardous drugs Middle Aged United States Cross-Sectional Studies Family medicine Workforce Female business medicine.drug |
| Zdroj: | Journal of Occupational & Environmental Medicine. 52:1019-1027 |
| ISSN: | 1076-2752 |
| Popis: | This study evaluated health care worker exposure to antineoplastic drugs.A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay.Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay.Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations. |
| Databáze: | OpenAIRE |
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