Influence of different B-complex recombinants on the outcome of Rous sarcomas in chickens
| Autor: | P. A. Aeed, W. E. Briles, W. M. Collins, Robert M. Zsigray |
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| Rok vydání: | 2009 |
| Předmět: |
Sarcoma
Avian Genotype Recombinant Haplotype viruses Immunogenetics Virus Major Histocompatibility Complex Histocompatibility Antigens Genetics medicine Animals Rous sarcoma virus biology Haplotype General Medicine Cell Transformation Viral biology.organism_classification medicine.disease Virology B vitamins Haplotypes Neoplasm Regression Spontaneous Animal Science and Zoology Sarcoma Chickens |
| Zdroj: | Animal Genetics. 24:177-181 |
| ISSN: | 1365-2052 0268-9146 |
| DOI: | 10.1111/j.1365-2052.1993.tb00283.x |
| Popis: | Summary Seven major histocompatibility (B) complex recombinants were evaluated for anti-Rous sarcoma response. In experiment 1, the BR5(F21-G19) recombinant haplotype both homozygous and in heterozygous combinations with B19 and B21 haplotypes were compared to B19/B19 and B21/B21 chickens to determine the relative influence of the BF versus BG chromosomal segments on regression of Rous sarcoma virus-induced tumours. In experiment 2, six recombinant haplotypes BR1(F24-G23), BR2(F2-G23), BR3(F2-G23), BR4(F2-G23), BR6(F21-G23) and BR8(F2-G2a,23) present in chickens heterozygous for normal haplotypes B19, B23 or B26 were compared for anti-sarcoma response. A total of 1328 chickens were blood typed for B alloanti-gens at 17 days of age, inoculated in the wingweb with Rous sarcoma virus at 6 weeks and monitored for anti-tumour immune response over a 10-week period. Genotypes which shared the same BF haplotype, but differed in their BG regions, had similar anti-tumour responses, implicating the BF but not the BG region in tumour regression. Chickens carrying BF2 or BF21 had a strong anti-tumour response, while BF24 conferred a weaker response, regardless of the accompanying normal haplotype. |
| Databáze: | OpenAIRE |
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