Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores

Autor:	Zhichuan Li, Danxin Wang, Liang Zhao, Scott A. Mosley, Yan Gong, Rhonda M. Cooper-DeHoff, Minori Kinjo, Reginald F. Frye, Cameron D. Thomas, Taimour Y. Langaee, Arlene B. Chapman, Sarah Kim, Hyewon Kim, Larisa H. Cavallari, Issam Hamadeh, John G. Gums, David S. Estores, Siegfried Schmidt, Lanyan Fang, Julie A. Johnson, Stephan Schmidt, Nihal El Rouby, Karthik Lingineni, Kairui Feng, Philip F. Binkley
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty CYP2D6 Genotype Administration Oral Blood Pressure Polymorphism Single Nucleotide Gastroenterology Article Pharmacokinetics Heart Rate Internal medicine Heart rate medicine Humans Pharmacology (medical) Prospective Studies Aged Metoprolol business.industry Research Significant difference Articles Middle Aged Adrenergic beta-1 Receptor Antagonists Clinical Practice Phenotype Cytochrome P-450 CYP2D6 Pharmacogenetics Modeling and Simulation Pharmacodynamics Female business medicine.drug
Zdroj:	CPT: Pharmacometrics & Systems Pharmacology
ISSN:	2163-8306
Popis:	Recent CYP2D6 phenotype standardization efforts by CYP2D6 activity score (AS) are based on limited pharmacokinetic (PK) and pharmacodynamic (PD) data. Using data from two independent clinical trials of metoprolol, we compared metoprolol PK and PD across CYP2D6 AS with the goal of determining whether the PK and PD data support the new phenotype classification. S‐metoprolol apparent oral clearance (CLo), adjusted for clinical factors, was correlated with CYP2D6 AS (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865a939c33b29804489eb9554d543c0 https://doi.org/10.1002/psp4.12563 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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