Elevated Cholesteryl Ester Transfer Protein Activity in IDDM Men Who Smoke: Possible Factor for Unfavorable Lipoprotein Profile
| Autor: | H Doorenbos, Bert D. Dikkeschei, D. W. Erkelens, J.E.M. Groener, Robin P. F. Dullaart |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein Lipoproteins Endocrinology Diabetes and Metabolism chemistry.chemical_compound Internal medicine Diabetes mellitus Cholesterylester transfer protein Internal Medicine medicine Humans Glycoproteins Advanced and Specialized Nursing biology Cholesterol business.industry Smoking Case-control study Middle Aged medicine.disease Pathophysiology Cholesterol Ester Transfer Proteins Apolipoproteins Diabetes Mellitus Type 1 Endocrinology chemistry Case-Control Studies biology.protein Cholesteryl ester lipids (amino acids peptides and proteins) Cholesterol Esters Carrier Proteins business Lipoprotein |
| Zdroj: | Diabetes Care. 14:338-341 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.14.4.338 |
| Popis: | Objectives To determine the effect of cigarette smoking on the activity of cholesteryl ester transfer protein (CETP) and high-density (HDL), low-density (LDL), and very-low-density (VLDL) lipoproteins in insulindependent diabetic (IDDM) men with microvascular complications. Research Design and Methods We perfomed a case-control study in a referral-based diabetes clinic on a sequential sample of 9 cigarettesmoking and 12 nonsmoking IDDM men with microvascular complications and 12 nonsmoking control men. CETP activity was determined in each serum with an isotope assay with exogenous cholesteryl esterlabeled LDL and HDL. The method is independent of the endogenous lipoprotein present in serum. Results The HDL-cholesterol (VLDL and LDL) ratio was lower in the smoking diabetic men than in the other groups (P < 0.05 vs. the nonsmoking diabetic men and P Conclusions CETP activity is increased in cigarette-smoking IDDM men with microvascular complications. High CETP activity may contribute to the unfavorable lipoprotein profile in these patients. |
| Databáze: | OpenAIRE |
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