Lower Respiratory Viral Illnesses
| Autor: | Paola M. Soccal, Laurent P. Nicod, Jorge Garbino, Jacques Schrenzel, Werner Wunderli, Yves Thomas, Béatrice Alice Bescher Ninet, Laurent Kaiser, Sabine Yerly, Christelle Deffernez, Luc Perrin, Margaret W. Gerbase, Thierry Rochat |
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| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Mycoplasma pneumoniae viruses Critical Care and Intensive Care Medicine medicine.disease_cause Immunocompromised Host medicine Humans Respiratory system Respiratory Tract Infections ddc:616 Lung medicine.diagnostic_test Respiratory tract infections business.industry Incidence Bronchoalveolar Lavage Fluid/microbiology/virology Respiratory infection respiratory system Gram-Negative Bacterial Infections/ diagnosis/immunology respiratory tract diseases Lung Transplantation/immunology Treatment Outcome Bronchoalveolar lavage medicine.anatomical_structure Virus Diseases Chlamydophila pneumoniae Immunology Rhinovirus Gram-Negative Bacterial Infections Virus Diseases/ diagnosis/immunology/virology business Bronchoalveolar Lavage Fluid Respiratory Tract Infections/ diagnosis/immunology/microbiology/virology Switzerland Lung Transplantation |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine, Vol. 170, No 11 (2004) pp. 1197-1203 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200406-781oc |
| Popis: | We assessed the frequency and the potential role of respiratory viruses on disease outcomes in hospitalized patients and lung transplant recipients who underwent a bronchoalveolar lavage (BAL) for an acute respiratory infection. BAL specimens (148) were analyzed by reverse transcription-polymerase chain reaction for the presence of 11 different viruses, as well as Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. Respiratory viruses were identified in 34 of 117 BAL specimens (29%) obtained in patients with a suspected respiratory infection and in only 2 of 31 control subjects (7%) (p < 0.01). M. pneumoniae was identified in five additional cases. Only 30% of cases that were virus positive by molecular methods were also positive by cell culture analysis. Rhinovirus was the most frequently identified virus (56% of cases) followed by respiratory syncytial virus (27%). In lung transplant recipients, the rate of viral infections was 55% in cases with respiratory symptoms compared with only 4% in control subjects (p < 0.001). In these cases, respiratory viral infections were associated with significant lung function abnormalities. By using reverse transcription-polymerase chain reaction assays, we frequently identified respiratory viruses in BAL specimens of patients hospitalized with lower respiratory tract infections. These viruses were associated with high morbidity, particularly in lung transplant recipients. |
| Databáze: | OpenAIRE |
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