Comprehensive systematic surveillance for adverse effects of anthrax vaccine adsorbed, US Armed Forces, 1998-2000
| Autor: | Sandra E. Lesikar, Jeffrey L. Lange, Mark V. Rubertone, John F. Brundage |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anthrax Vaccines Public health surveillance Environmental health medicine Ambulatory Care Confidence Intervals Humans Adverse effect Military Medicine Aged Retrospective Studies Anthrax vaccines General Veterinary General Immunology and Microbiology business.industry Public health Public Health Environmental and Occupational Health Anthrax Vaccine Adsorbed Middle Aged United States Vaccination Hospitalization Military personnel Infectious Diseases Military Personnel Population Surveillance Emergency medicine Cohort Multivariate Analysis Molecular Medicine Female business Follow-Up Studies |
| Zdroj: | Vaccine. 21(15) |
| ISSN: | 0264-410X |
| Popis: | Routine vaccinations of US military personnel with Anthrax Vaccine Adsorbed began in 1998. To systematically identify clinical diagnoses reported more frequently after vaccination than before, all military personnel were retrospectively assigned to pre- or post-vaccination cohorts. Cohort assignments were based on vaccination statuses each day of the 3-year surveillance period. For each cohort, rates of hospitalizations and ambulatory visits for 843 specific diagnoses were calculated using data in a public health surveillance system. Compared to the pre-vaccination cohort, the post-vaccination cohort had statistically higher rates of hospitalizations for 17 diagnoses, of ambulatory visits for 34 diagnoses, and in both clinical settings for one diagnosis (malaria). After accounting for systematic differences in coding/reporting and residual confounding, the number and nature of clinical diagnoses more frequent after anthrax vaccination than before were consistent with expectations due to random variation. This surveillance suggests that Anthrax Vaccine Adsorbed has few, if any, clinically significant adverse effects. |
| Databáze: | OpenAIRE |
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