Acute effects of Adaptive Deep Brain Stimulation in Parkinson’s disease
| Autor: | Dan Piña-Fuentes, Martijn Beudel, Marc J.M.C van Dijk, Harmen R Moes, Marinus D.L.M. Oterdoom, Jonathan C. van Zijl, Simon Little, Peter Brown |
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| Rok vydání: | 2019 |
| Předmět: |
Acute effects
0303 health sciences medicine.medical_specialty Parkinson's disease Deep brain stimulation business.industry Disease duration medicine.medical_treatment Stimulation medicine.disease 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine medicine Cardiology In patient business 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/749903 |
| Popis: | BackgroundBeta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson’s disease (PD), when assessed in the immediate post-implantation phase. However, the potential benefits of aDBS in patients with electrodes chronically implanted, in whom the benefits of the microlesion effect have disappeared, are yet to be assessed.MethodsTo determine the acute effectiveness and side-effect profile of aDBS in PD compared to conventional continuous DBS (cDBS) and no stimulation (NoStim), years after DBS implantation. 13 PD patients undergoing battery replacement were pseudo-randomised in a crossover fashion, in- to three conditions (NoStim, aDBS or cDBS). Patient videos were blindly evaluated using a short version of the Unified Parkinson’s Disease Rating Scale (subUPDRS) and the Speech Intelligibility Test (SIT).ResultsPatients had a mean disease duration of 16 years, and the mean time since DBS implantation was 6.9 years. subUPDRS scores (11 patients tested) were significantly lower both in aDBS (p=ConclusionBeta oscillations is effective in PD patients with bradykinetic phenotypes, delivers less stimulation than cDBS, and potentially has a more favourable speech side-effect profile. Patients with prominent tremor may require a modified adaptive control strategy. |
| Databáze: | OpenAIRE |
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