Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats
| Autor: | Yoshihisa Fujikura, Taiga Ninomiya, Jusen Tsuru, Yoshihiro Tanaka, Hirokazu Kitamura, Shuhei Honda, Koichi Isogawa, Yoshinobu Ishitobi, Masayuki Kanehisa, Jotaro Akiyoshi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Emotions Appetite Hippocampus Anxiety DNA Antisense Receptors G-Protein-Coupled Anxiolytic like Eating Lateral ventricles Internal medicine medicine Animals Rats Wistar Receptor media_common Antisense DNA Behavior Animal General Neuroscience Body Weight Alternative splicing General Medicine Obestatin Rats Endocrinology Dentate Gyrus Psychology |
| Zdroj: | Neuroscience Research. 72:257-262 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/j.neures.2011.12.002 |
| Popis: | The G protein-coupled receptor 39-b (GPR39-1b) is a splice variant of which is expressed in the central nervous and gastrointestinal systems. Previously, GPR39-1b was proposed to be the receptor for obestatin, but current evidence does not support this hypothesis. The purpose of the present work was to identify the role of GPR39-1b in anxiety and eating behaviors. Antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety-like behavior and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test and in the black and white box test. Antisense oligonucleotides also decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite. |
| Databáze: | OpenAIRE |
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