Within-Host and Population Transmission of blaOXA-48 in K. pneumoniae and E. coli
| Autor: | Haverkate, Manon R, Dautzenberg, Mirjam J D, Ossewaarde, Tjaco J M, van der Zee, Anneke, den Hollander, Jan G, Troelstra, Annet, Bonten, Marc J M, Bootsma, Martin C J, Sub Mathematical Modeling, Mathematical Modeling |
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| Přispěvatelé: | Sub Mathematical Modeling, Mathematical Modeling |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Imipenem
Gene Transfer Horizontal Klebsiella pneumoniae medicine.drug_class Population Antibiotics lcsh:Medicine Drug resistance Research Support medicine.disease_cause Meropenem beta-Lactamases Microbiology Antibiotic resistance Drug Resistance Bacterial polycyclic compounds Escherichia coli medicine Journal Article Humans Non-U.S. Gov't lcsh:Science education Escherichia coli Infections education.field_of_study Multidisciplinary integumentary system biology Escherichia coli Proteins Research Support Non-U.S. Gov't lcsh:R biochemical phenomena metabolism and nutrition biology.organism_classification Klebsiella Infections 3. Good health bacteria lcsh:Q Research Article medicine.drug |
| Zdroj: | PLoS ONE [E], 10(10). Public Library of Science PLoS ONE PLoS ONE, Vol 10, Iss 10, p e0140960 (2015) PLoS One, 10(10). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | During a large hospital outbreak of OXA-48 producing bacteria, most K. pneumoniae OXA-48 isolates were phenotypically resistant to meropenem or imipenem, whereas most E. coli OXA-48 isolates were phenotypically susceptible to these antibiotics. In the absence of molecular gene-detection E. coli OXA-48 could remain undetected, facilitating cross-transmission and horizontal gene transfer of bla OXA-48. Based on 868 longitudinal molecular microbiological screening results from patients carrying K. pneumoniae OXA-48 (n = 24), E. coli OXA-48 (n = 17), or both (n = 40) and mathematical modelling we determined mean durations of colonisation (278 and 225 days for K. pneumoniae OXA-48 and E. coli OXA-48, respectively), and horizontal gene transfer rates (0.0091/day from K. pneumoniae to E. coli and 0.0015/day vice versa). Based on these findings the maximum effect of horizontal gene transfer of bla OXA-48 originating from E. coli OXA-48 on the basic reproduction number (R 0) is 1.9%, and it is, therefore, unlikely that phenotypically susceptible E. coli OXA-48 will contribute significantly to the spread of bla OXA-48. |
| Databáze: | OpenAIRE |
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