Solubilization of flavopiridol by pH control combined with cosolvents, surfactants, or complexants
| Autor: | Samuel H. Yalkowsky, S. Esmail Tabibi, Ping Li |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Flavonoids
chemistry.chemical_classification Cyclodextrin Pharmaceutical Science Antineoplastic Agents Ether Hydrogen-Ion Concentration Micelle Inclusion compound Excipients Partition coefficient Surface-Active Agents chemistry.chemical_compound Piperidines Solubility Pulmonary surfactant chemistry Solvents Organic chemistry Polysorbate 20 Chromatography High Pressure Liquid Micelles Nuclear chemistry |
| Zdroj: | Journal of Pharmaceutical Sciences. 88:945-947 |
| ISSN: | 0022-3549 |
| DOI: | 10.1021/js990097r |
| Popis: | This study investigates the roles of both ionized and un-ionized species of flavopiridol in solubilization by complexation, micellization, and cosolvency. Control of pH was used in combination with surfactants (polysorbate 20 and polysorbate 80), cosolvents (ethanol and propylene glycol), as well as uncharged and anionic complexing agents [hydroxypropyl beta-cyclodextrin (HPbetaCD) and sulfobutyl ether beta-cyclodextrin (SBEbetaCD)] to solubilize flavopiridol. These combined techniques increase not only the solubility of the un-ionized flavopiridol but also the solubility of the ionized drug. This study confirms that previously developed equations effectively characterize the roles of pH, pK(a), and either complexation constant, micelle partition coefficient, or cosolvent solubilizing power in determining drug total aqueous solubility. |
| Databáze: | OpenAIRE |
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