Association between long noncoding RNA rs944289 and rs7990916 polymorphisms and the risk of colorectal cancer in a Chinese population
| Autor: | Yan Xi, Zhiyuan Qiu, Yan Wang, Guang-Yu Tian, Qianqian Zhu, Zhao Zhang, Yong Peng, Sheng Zhang, Rong Qin, Weifeng Tang |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Oncology China medicine.medical_specialty Alcohol Drinking Carcinogenesis Colorectal cancer Polymorphism Single Nucleotide Asian People Risk Factors Internal medicine Humans Medicine Genetic Predisposition to Disease Aged Chinese population Multidisciplinary business.industry Homozygote Smoking Middle Aged medicine.disease Long non-coding RNA Case-Control Studies Female RNA Long Noncoding Colorectal Neoplasms business |
| Zdroj: | Scientific Reports. 12 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-022-06474-3 |
| Popis: | Long non-coding RNAs (LncRNAs) play vital roles in the tumorigenesis of many cancers. Single nucleotide polymorphisms (SNPs) of the lncRNA also play vital roles in tumorigenesis. We explored lncRNA rs944289 and rs7990916 polymorphisms and analyzed the relationship between these lncRNA polymorphisms with the colorectal cancer (CRC) risk in a Chinese population. We recruited 1,003 CRC patients from the Affiliated People’s Hospital of Jiangsu University and the Fujian Medical University Union Hospital from October 2014 to August 2017. Genomic DNA was extracted using a DNA Kit from lymphocytes of peripheral blood and the genotyping was performed with a SNPscan method. We found that the rs944289 TT homozygote was associated with the decreased CRC risk. However, there was no statistically significant association between lncRNA rs7990916 polymorphism and the CRC risk. LncRNA rs944289 TT decreased the CRC risk in the subgroup of female by logistic regression, male, age≥61, without alcohol intake, smoking and BMI≥24. The subgroup analysis revealed that lncRNA rs7990916 was not associated with the CRC risk except for ageP=0.041) or colon cancer. In summary, we proved that the lncRNA rs944289 might be significantly related to the decreased CRC risk in the Chinese Han populations and lncRNA rs7990916 was not associated with the CRC risk except for patients of age |
| Databáze: | OpenAIRE |
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