Y chromosome haplogroups in autistic subjects
| Autor: | Anne Philippe, Catalina Betancur, Hélène Quach, Stéphane Jamain, Thomas Bourgeron, Marc Fellous, Eili Sponheim, Ola H. Skjeldal, Luis Quintana-Murci, Christopher Gillberg, Marion Leboyer |
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| Přispěvatelé: | Génomique fonctionnelle et développement, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurobiologie et Psychiatrie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Child and Adolescent Psychiatry, University of Gothenburg (GU), Centre for Child and Adolescent Psychiatry, University of Oslo (UiO), Department of Pediatrics, University of Oslo (UiO)-Rikshospitalet, Département de Psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Albert Chenevier, This work was supported by the Délégation de la Recherche Clinique de l'Assistance Publique-Hôpitaux de Paris (PHRC AOM95076 and CRC 932413), the French Research Ministry (Actions Concertées Incitatives), France Télécom, and the Swedish Medical Research Council (grant no. K97-21X-11251-03CK). LQH is an INSERM Poste Vert., Paris Autism Research International Sibpair (PARIS) study, Betancur, Catalina, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Genetic Markers
Male haplotypes Population autism [SDV.GEN] Life Sciences [q-bio]/Genetics Biology Y chromosome Haplogroup Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Sex Factors Y Chromosome medicine Humans Autistic Disorder sex chromosome education Child Molecular Biology X chromosome 030304 developmental biology Genetics 0303 health sciences education.field_of_study [SDV.GEN]Life Sciences [q-bio]/Genetics Haplotype medicine.disease Developmental disorder Psychiatry and Mental health gender difference Autism Female polymorphisms 030217 neurology & neurosurgery Sex linkage |
| Zdroj: | Molecular Psychiatry Molecular Psychiatry, 2002, 7 (2), pp.217-219. ⟨10.1038/sj.mp.4000968⟩ Molecular Psychiatry, Nature Publishing Group, 2002, 7 (2), pp.217-219. ⟨10.1038/sj.mp.4000968⟩ |
| ISSN: | 1359-4184 1476-5578 |
| DOI: | 10.1038/sj.mp.4000968⟩ |
| Popis: | The male to female ratio in autism is 4:1 in the global autistic population, but increases to 23:1 in autistic subjects without physical or brain abnormalities. 1 Despite this well-recognised gender difference, male predisposition to autistic disorder remains unexplained and the role of sex chromosomes is still debated. Numerical and structural abnormalities of the sex chromosomes are among the most frequently reported chromosomal disorders associated with autism. However, genome scans have failed to detect linkage on the X chromosome chromosome2–4 and this approach cannot study the non-recombining region of the Y chromosome. In this study, we searched for a specific Y chromosome effect in autistic subjects. Using informative Y-polymorphic markers, the Y chromosome haplotypes of 111 autistic subjects from France, Sweden and Norway were defined and compared with relevant control populations. No significant difference in Y- haplotype distribution between the affected and control groups was observed. Although this study cannot exclude the presence of a Y susceptibility gene, our results are not suggestive of a Y chromosome effect in autism. |
| Databáze: | OpenAIRE |
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