Rewarding Effects of AMPA Administration into the Supramammillary or Posterior Hypothalamic Nuclei But Not the Ventral Tegmental Area
| Autor: | Brian M Witkin, Satoshi Ikemoto, Abraham Zangen, Roy A. Wise |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Hypothalamus Posterior Mammillary Bodies Dopamine Microdialysis Self Administration Behavioral/Systems/Cognitive AMPA receptor Nucleus accumbens Injections Structure-Activity Relationship chemistry.chemical_compound Reward Conditioning Psychological medicine Animals Receptors AMPA Rats Wistar alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid SCH-23390 musculoskeletal neural and ocular physiology General Neuroscience Ventral Tegmental Area Stereoisomerism Conditioned place preference Rats Ventral tegmental area medicine.anatomical_structure nervous system chemistry Hypothalamus CNQX Excitatory postsynaptic potential Reinforcement Psychology Neuroscience |
| Zdroj: | The Journal of Neuroscience. 24:5758-5765 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | We examined whether injections of the excitatory amino acid AMPA are rewarding when injected into the posterior hypothalamus and ventral tegmental area. Rats quickly learned to lever-press for infusions of AMPA into the supramammillary or posterior hypothalamic nuclei but failed to learn to lever-press for similar injections into the ventral tegmental areas. AMPA injections into the supramammillary nucleus, but not the ventral tegmental area, induced conditioned place preference. The rewarding effects of AMPA appear to be mediated by AMPA receptors, because coadministration of the AMPA antagonist CNQX blocked the rewarding effects of AMPA, and administration of the enantiomerR-AMPA did not mimic the rewarding effects. AMPA injections into the supramammillary nucleus, but not the ventral tegmental area, also increased extracellular dopamine concentrations in the nucleus accumbens. Pretreatment with the D1dopamine antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine] led to extinction of AMPA self-administration. These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently. |
| Databáze: | OpenAIRE |
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