Selenite is a potent cytotoxic agent for human primary AML cells
| Autor: | Sören Lehmann, Aristi P. Fernandes, Anna-Klara Rundlöf, Inmaculada Ribera-Cortada, Lennart Eriksson, Mikael Björnstedt, Eric Olm, Kerstin Jönsson-Videsäter, C. Paul |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research Myeloid Cell Survival Drug resistance Biology Pharmacology Adenosine Triphosphate Sodium Selenite Bone Marrow medicine Humans Cytotoxic T cell Cytotoxicity Aged Aged 80 and over Cytotoxins Myeloid leukemia Middle Aged medicine.disease Immunohistochemistry In vitro Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology Female Ex vivo |
| Zdroj: | Cancer Letters. 282:116-123 |
| ISSN: | 0304-3835 |
| Popis: | Selenite is a potent inhibitor of malignant cell growth. Although the cytotoxic effects have been extensively investigated in vitro, there are only a limited number of studies using primary tumor cells with concomitant comparison to conventional drugs. An ex vivo model with primary cells from 39 consecutive patients with acute myeloid leukemia (AML) were exposed to a panel of conventional cytotoxic drugs, and the effects on viability were compared to those of clinically achievable concentrations of selenite. Selenite at 5 microM caused the lowest mean survival of primary tumor cells in the panel of all tested drugs (28.95% CI 18.60-39.30%). The cells showed a significant (p |
| Databáze: | OpenAIRE |
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