SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients
| Autor: | Vittorio Sambri, Teresa Santantonio, Livio Pagano, Stefano Andreoni, Filomena Puntillo, F. Di Bernardo, C Coretti, Claudio Viscoli, Maurizio Sanguinetti, Patrizia Pecile, Lucia Pitzurra, O De Giglio, Giorgina Specchia, Malgorzata Mikulska, Domenico Martinelli, G. Lombardi, Anna Candoni, Giuseppina Caggiano, Ercole Concia, G Lovero, Mario Delia, Domenico D'Antonio, R. Masciari, Claudio Farina, Maria Teresa Montagna, Morena Caira, Natalia Maximova, Anna Maria Barbui, G. Lo Cascio, Salvatore Massimo Oliveri, Mario Venditti, Francesco Barchiesi, Pierluigi Viale |
|---|---|
| Přispěvatelé: | M. T. Montagna, G. Lovero, C. Coretti, D. Martinelli, M. Delia, O. D. Giglio, M. Caira, F. Puntillo, D. D'Antonio, M. Venditti, V. Sambri, F. D. Bernardo, A. Barbui, G. L. Cascio, E. Concia, M. Mikulska, C. Viscoli, N. Maximova, A. Candoni, S. Oliveri, G. Lombardi, L. Pitzurra, M. Sanguinetti, R. Masciari, T. Santantonio, S. Andreoni, F. Barchiesi, P. Pecile, C. Farina, P. Viale, G. Specchia, G. Caggiano, L. Pagano |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Microbiological Techniques Hematological patients Prevalence Aspergillosis 80 and over Diagnostic Test Non-hematological patients Epidemiology Filamentous fungal infections Italian survey 80 and over aspergillosis Prospective Studies Registries Prospective cohort study Aged 80 and over General Medicine Middle Aged Hospitals Infectious Diseases Treatment Outcome Italy Hematologic Neoplasms Female Microbiology (medical) Adult medicine.medical_specialty methods Middle Aged Mycose Adolescent Neutropenia Clinical and Epidemiological Study Young Adult Pharmacotherapy Diagnostic Tests Internal medicine medicine Humans Routine Female Fungi Routine epidemiology Male Microbiological Technique Aged complications Hospitals Humans Italy classification/isolation /&/ purification Hematologic Neoplasm business.industry Diagnostic Tests Routine fungal infection Mucormycosis Fungi hematological patients italian survey hematological and non-hematological patients non-hematological patients filamentous fungal infections italy fungal infections medicine.disease Survival Analysis diagnosis/epidemiology/microbiology/mortality Prospective Studies Registries Survival Analysis Treatment Outcome Young Adult Settore MED/15 - MALATTIE DEL SANGUE Mycoses Adolescent Adult Aged Aged Immunology Etiology business |
| Zdroj: | Infection |
| Popis: | Purpose We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs). Methods Prospective surveillance (2009–2011) of proven and probable FFIs was implemented in 23 Italian hospitals. Results Out of 232 FFIs, 113 occurred in HAEs and 119 in non-HAEs. The most frequent infection was invasive aspergillosis (76.1 % for HAEs, 56.3 % for non-HAEs), and the localization was principally pulmonary (83.2 % for HAEs, 74.8 % for non-HAEs). Neutropenia was a risk factor for 89.4 % HAEs; the main underlying condition was corticosteroid treatment (52.9 %) for non-HAEs. The distribution of proven and probable FFIs was different in the two groups: proven FFIs occurred more frequently in non-HAEs, whereas probable FFIs were correlated with the HAEs. The sensitivity of the galactomannan assay was higher for HAEs than for non-HAEs (95.3 vs. 48.1 %). The overall mortality rate was 44.2 % among the HAEs and 35.3 % among the non-HAEs. The etiology influenced the patient outcomes: mucormycosis was associated with a high mortality rate (57.1 % for HAEs, 77.8 % for non-HAEs). Conclusions The epidemiological and clinical data for FFIs were not identical in the HAEs and non-HAEs. The differences should be considered to improve the management of FFIs according to the patients’ setting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|