Anti-tumor Effect of L-methionine-Deprived Total Parenteral Nutrition with 5-Fluorouracil Administration on Yoshida Sarcoma-bearing Rats
| Autor: | Mitsuo Endo, Goro Kosaki, Narihide Goseki, Tokio Onodera |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Metastasis chemistry.chemical_compound Methionine Cause of Death Internal medicine Animals Medicine Neoplasm Metastasis Sarcoma Yoshida Antitumor activity Chemotherapy business.industry Body Weight medicine.disease Combined Modality Therapy Primary tumor Yoshida Sarcoma Rats Survival Rate Disease Models Animal Endocrinology Parenteral nutrition chemistry Evaluation Studies as Topic Fluorouracil Parenteral Nutrition Total Surgery business Research Article medicine.drug |
| Zdroj: | Annals of Surgery. 214:83 |
| ISSN: | 0003-4932 |
| Popis: | L-methionine-deprived total parenteral nutrition (methionine-deprived TPN), infusing amino acid solution devoid of L-methionine and L-cysteine by the method of TPN as an only protein source, showed enhancement of the effect of several anti-cancer agents. In this study the combined effect of the methionine-deprived TPN with administration of 5-fluorouracil (5-FU) was examined in Yoshida Sarcoma (YS)-bearing rats, from aspects of effects on the tumor metastasis and the host animal's life span, in the following four groups treated with: methionine-deprived TPN with administration of 5-FU, methionine-deprived TPN without administration of 5-FU, L-methionine-contained TPN plus 5-FU, and L-methionine-contained TPN without 5-FU. In the first experiment, TPN was continued for 8 days in the four groups, and the anti-cancer effect of methionine-deprived TPN and administration of 5-FU based on both the growth of the primary tumor at the implanted site and the tumor metastasis was studied from the view point of pathologic findings of animals killed immediately after these treatments. In experiment 2 the survival period was examined after these treatments for 10 days with subsequent oral feeding until death. The results were as follows: proliferation of YS, transplanted subcutaneously, was markedly suppressed; particularly hematogenous metastasis, characteristic in YS, was prominently blunted then obtained an apparent longer survival period in rats treated with the methionine-deprived TPN with administration of 5-FU. |
| Databáze: | OpenAIRE |
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