Genes Associated with Leukocyte Production in Mice

Autor:	Chai Ck
Rok vydání:	1975
Předmět:	Genetics Genetic Linkage Mutant Locus (genetics) Biology Selective breeding Crossbreed Hematopoiesis Leukocyte Count Mice Genes Genetic linkage Polygene Leukocytes Animals Hybridization Genetic Molecular Biology Gene Crosses Genetic Genetics (clinical) Biotechnology Dominance (genetics)
Zdroj:	Journal of Heredity. 66:301-308
ISSN:	1465-7333 0022-1503
DOI:	10.1093/oxfordjournals.jhered.a108634
Popis:	We have investigated the genes influencing leukocyte production in mice by selective breeding for differences in leukocyte count and developed two major lines differing about 8-fold. In these lines we have made counter selective breeding, crossbreeding between them, and developed methods of using marker genes to search for individual genes distributed on different chromosomes. We have revealed an overall dominance of genes for low leukocyte count over those for high counts, and effects of genes at the agouti locus, certain mutant genes, and a gene or genes in the XVI linkage group. We have commented on the application and approach of quantitative genetic experimentation from both a theoretical and practical point of view and, on the basis of present results, discussed the nature of polygenes in relation to genes causing polymorphisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58530f025b3b0b2d5dee8ee754f47c9a https://doi.org/10.1093/oxfordjournals.jhered.a108634 Zobrazit plný text záznamu