Reversible gonadotropin Deficiency in Male Cushing's Dusease
| Autor: | Bricaire H, Jean-Claude Valcke, Jacques A. Mahoudeau, Philippe Thieblot, Jean-Pierre Luton |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hydrocortisone medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Gonadotropin-releasing hormone Chorionic Gonadotropin Biochemistry Gonadotropin-Releasing Hormone Cushing syndrome Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Hypogonadotropic hypogonadism Internal medicine Humans Medicine Testosterone Cushing Syndrome Normal range business.industry Biochemistry (medical) Luteinizing Hormone Middle Aged Gonadotropin deficiency medicine.disease Gonadotropins Pituitary Mitotane Follicle Stimulating Hormone Gonadotropin business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 45:488-495 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-45-3-488 |
| Popis: | Twelve adult males with documented active Cushing's disease were studied. Mean plasma testosterone (T) was significantly decreased: 1.8 +/- 0.3 (SEM) ng/ml (N=6.8 +/- 0.5); gonadotropin measurements in 8 patients, in basal conditions and under LH-RH iv, showed a significant decrease in both FSH and LH. A further study of 11 patients in remission of Cushing's disease indicated a significant increase in plasma T and gonadotropins up to the normal range. One patient with an initial low T value had a normalized T while in remission, then a dramatic decrease when the disease relapsed. We conclude: a hypogonadotropic hypogonadism is found in male Cushing's disease; it disappears as early as hypercortisolism is suppressed. Some possible mechanisms are discussed. |
| Databáze: | OpenAIRE |
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