Reconstructing the household transmission of influenza in the suburbs of Tokyo based on clinical cases
| Autor: | Yoshitake Kitanishi, Takamichi Baba, Nobuo Hirotsu, Keisuke Honda, Masaya M. Saito, Hiroka Hamada, Takahiro Hasegawa, Mio Takei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Demographics medicine.drug_class Health Informatics lcsh:Computer applications to medicine. Medical informatics Incubation period Household transmission 03 medical and health sciences 0302 clinical medicine Mathematical model Japan Influenza Human medicine Humans 030212 general & internal medicine Tokyo lcsh:QH301-705.5 Probability Family Characteristics Neuraminidase inhibitor Transmission (medicine) business.industry Research Public health Stochastic simulation Infectious period 030112 virology Influenza lcsh:Biology (General) Modeling and Simulation Secondary attack ratio lcsh:R858-859.7 business Demography |
| Zdroj: | Theoretical Biology and Medical Modelling, Vol 18, Iss 1, Pp 1-10 (2021) Theoretical Biology & Medical Modelling |
| ISSN: | 1742-4682 |
| Popis: | BackgroundInfluenza is a public health issue that needs to be addressed strategically. The assessment of detailed infectious profiles is an important part of this effort. Household transmission data play a key role in estimating such profiles. We used diagnostic and questionnaire-based data on influenza patients at a Japanese clinic to estimate the detailed infectious period (as well as incubation period, symptomatic and infectious periods, and extended infectious period after recovery) and the secondary attack ratio (SAR) of influenza for households of various sizes based on a modified Cauchemez-type model.ResultsThe data were from enrolled patients with confirmed influenza who were treated at the Hirotsu Clinic (Kawasaki, Japan) with a neuraminidase inhibitor (NAI) during six northern hemisphere influenza seasons between 2010 and 2016. A total of 2342 outpatients, representing 1807 households, were included. For influenza type A, the average incubation period was 1.43 days (95% probability interval, 0.03–5.32 days). The estimated average symptomatic and infective period was 1.76 days (0.33–4.62 days); the extended infective period after recovery was 0.25 days. The estimated SAR rose from 20 to 32% as household size increased from 3 to 5. For influenza type B, the average incubation period, average symptomatic and infective period, and extended infective period were estimated as 1.66 days (0.21–4.61), 2.62 days (0.54–5.75) and 1.00 days, respectively. The SAR increased from 12 to 21% as household size increased from 3 to 5.ConclusionAll estimated periods of influenza type B were longer than the corresponding periods for type A. However, the SAR for type B was less than that for type A. These results may reflect Japanese demographics and treatment policy. Understanding the infectious profiles of influenza is necessary for assessing public health measures. |
| Databáze: | OpenAIRE |
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