Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus
| Autor: | J. Dyerberg, Heidi Storgaard, Camilla Spohr, Charlotte Brøns, Allan Vaag |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Taurine endocrine system diseases medicine.medical_treatment Medicine (miscellaneous) Type 2 diabetes chemistry.chemical_compound Double-Blind Method Internal medicine Diabetes mellitus Insulin Secretion medicine Humans Insulin Genetic Predisposition to Disease Obesity Pancreatic hormone Aged Glucose tolerance test Nutrition and Dietetics Cross-Over Studies medicine.diagnostic_test business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Glucose clamp technique Glucose Tolerance Test Middle Aged medicine.disease Lipids Endocrinology chemistry Diabetes Mellitus Type 2 Dietary Supplements Glucose Clamp Technique business |
| Zdroj: | European journal of clinical nutrition. 58(9) |
| ISSN: | 0954-3007 |
| Popis: | Background: The prevalence of type 2 diabetes mellitus (T2DM) is increasing with an epidemic growth rate. Animal studies with taurine supplementation have shown increased insulin secretion and action, suggesting that taurine supplementation may have a potential to prevent T2DM. Objective: To assess the effect of taurine treatment on insulin secretion and action, and on plasma lipid levels in overweight men with a positive history of T2DM. Design: 20 nondiabetic subjects were included in a double-blinded, randomized, crossover study, receiving a daily supplementation of 1.5 g taurine or placebo for two periods of 8 weeks. The subjects were overweight first-degree relatives of T2DM patients. An intravenous glucose tolerance test (IVGTT) was used to measure first-phase insulin secretory response, and a euglycemic hyperinsulinemic clamp was used to determine peripheral insulin action. Results: Mean plasma taurine concentration was 39±7 (s.d.) μmol/l after placebo and 131±62 μmol/l after taurine intervention (P |
| Databáze: | OpenAIRE |
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