Pulmonary Kirsten Rat Sarcoma Virus Mutation Positive Mucinous Adenocarcinoma Arising in a Congenital Pulmonary Airway Malformation, Mixed Type 1 and 2

Autor: Alain C. Borczuk, Robert C. Neely, Gopal Singh, Amy Coffey, Lyall A. Gorenstein, Daniel Lambert, Joshua R. Sonett
Rok vydání: 2016
Předmět:
Pathology
Lung Neoplasms
medicine.medical_treatment
030204 cardiovascular system & hematology
medicine.disease_cause
0302 clinical medicine
Pneumonectomy
Respiratory Tract Infections
medicine.diagnostic_test
Thoracic Surgery
Video-Assisted
Biopsy
Needle
Congenital pulmonary airway malformation
respiratory system
Adenocarcinoma
Mucinous
Immunohistochemistry
Treatment Outcome
medicine.anatomical_structure
030220 oncology & carcinogenesis
Adenocarcinoma
Female
KRAS
Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Adenocarcinoma of Lung
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
Cystic Adenomatoid Malformation of Lung
Congenital
Biopsy
medicine
Adenocarcinoma of the lung
Animals
Humans
neoplasms
Fetus
Lung
business.industry
medicine.disease
Rats
respiratory tract diseases
Chronic Disease
Mutation
Surgery
Tomography
X-Ray Computed
business
Kirsten murine sarcoma virus
Follow-Up Studies
Zdroj: The Annals of Thoracic Surgery. 102:e335-e337
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2016.01.104
Popis: Congenital pulmonary airway malformation (CPAM) is a developmental abnormality of the lung, which results from an abnormality of branching during fetal development of the lung. We report the case of an 18 year-old woman who developed Kirsten rat sarcoma virus (KRAS) mutation positive mucinous adenocarcinoma of the lung (AC) in association with mixed CPAM type 1 and 2. This case is unique as KRAS mutation positive AC is present in a setting of both CPAM 1 and 2 in the same lesion.
Databáze: OpenAIRE
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