Clinical and microbiological efficacy of levofloxacin administered three times a day for the treatment of bacterial conjunctivitis
| Autor: | J, Szaflik, J P, Szaflik, A, Kaminska, Justyna, Izdebska |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Ofloxacin Adolescent medicine.drug_class Antibiotics Levofloxacin law.invention 03 medical and health sciences Conjunctivitis Bacterial Young Adult 0302 clinical medicine Pharmacotherapy Randomized controlled trial law Internal medicine Medicine Humans Dosing Young adult Aged Bacterial Conjunctivitis Bacteria business.industry General Medicine Middle Aged Surgery Anti-Bacterial Agents Ophthalmology Treatment Outcome 030221 ophthalmology & optometry Patient Compliance Female Ophthalmic Solutions business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European journal of ophthalmology. 19(1) |
| ISSN: | 1120-6721 |
| Popis: | Purpose This randomized, investigator-masked study aimed to compare the clinical and microbiological effectiveness of three times daily administration of levofloxacin 0.5% eyedrops with the classic, more frequent dosing in patients with bacterial conjunctivitis. Methods A total of 120 patients with symptoms of bacterial conjunctivitis were enrolled. The patients were randomly assigned to receive 0.5% levofloxacin eyedrops three times daily to each eye for 5 days (experimental dosage group), or every 2 hours on days 1 and 2, and then every 4 hours on days 3–5 (up to four times per day) (classic dosage group). Ocular symptoms and signs were assessed on day 1, days 3 to 4, and 7 ± 1 visits. Conjunctival cultures were obtained at baseline and final visits. Clinical outcomes were based on resolution of cardinal signs. Microbial outcomes were based on culture results. Results Eighty-six patients (41 experimental dosage, 45 classic dosage) were evaluated. There was no difference between the groups in frequency of patients with clinical outcome resolved (85.4% in experimental vs 93.3% in classic dosage group, p=0.3). The microbial eradication rates did not differ statistically between the groups (92.7% vs 95.6%, respectively, p=0.67). Conclusions There was no statistically significant difference in the efficacy or safety between the two methods of drug administration. Analysis of the results of compliance supported our conclusion that the less frequent method of dosing of 0.5% levofloxacin eyedrops was more convenient for patients and resulted in better adherence to the drug-dosing scheme |
| Databáze: | OpenAIRE |
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