Imaging Features to Predict Response to Olfactory Training in Post‐Traumatic Olfactory Dysfunction

Autor: Sedat Giray Kandemirli, Aytug Altundag, Deniz Esin Tekcan Sanli, Duzgun Yildirim, Ozlem Saatci, Ozge Arici Duz, Ahmet Necati Sanli
Přispěvatelé: Tıp Fakültesi
Rok vydání: 2021
Předmět:
Adult
Male
Olfactory system
medicine.medical_specialty
Signal Detection
Psychological
Head-Trauma
Fossa
Olfactory Dysfunction
Sensitivity and Specificity
Olfactory Training
Olfaction Disorders
Young Adult
03 medical and health sciences
0302 clinical medicine
Olfactory nerve
Predictive Value of Tests
Reference Values
medicine
Craniocerebral Trauma
Humans
030223 otorhinolaryngology
Aged
Retrospective Studies
Sniffin’ Sticks Test
Medical treatment
biology
business.industry
Significant difference
Area under the curve
Reproducibility of Results
Middle Aged
Prognosis
biology.organism_classification
medicine.disease
Magnetic Resonance Imaging
Olfactory Bulb
Olfactory bulb
Treatment Outcome
Otorhinolaryngology
Sniffin' Sticks Test
Area Under Curve
Sensory Thresholds
Female
Radiology
Siderosis
business
030217 neurology & neurosurgery
Zdroj: The Laryngoscope. 131
ISSN: 1531-4995
0023-852X
DOI: 10.1002/lary.29392
Popis: Objectives/Hypothesis: Prognosis of post-traumatic olfactory dysfunction is poor, with medical treatment options showing limited success rates. Olfactory training (OT) has been introduced as a potential therapeutic option in olfactory dysfunction. We aimed to identify the imaging features that would predict a better response to OT and create an imaging-based prognostic scale. Methods: We retrospectively reviewed 52 patients that underwent OT at our center for post-traumatic olfactory dysfunction. Olfactory functions at the time of initial presentation and at completion of OT were evaluated using Sniffin’ Sticks test and threshold discrimination identification (TDI) scores were calculated. Patients were divided into responders (ROT group: 16 cases) and non-responders (n-ROT group: 36 cases) to OT based on TDI score change (cut-off 5.5 point). Morphological measurements of olfactory fossa, olfactory bulb volume and signal abnormalities, olfactory nerve filia integrity, siderosis, encephalomalacic changes in olfactory cortex, and other cortical regions were reviewed. Results: There was no significant difference between the two groups in terms of age, gender distribution, olfactory dysfunction duration, head-trauma severity, and initial TDI scores. A model incorporating five variables: cribriform plate fracture, olfactory fossa depth (cut-off: 4.9 mm), olfactory bulb encephalomalacia, olfactory bulb volume (cut-off: 27.1 mm3), and siderosis was developed. This model had an area under the curve (AUC) of 0.950, and a cut-off value of 1 had 76.5% sensitivity and 97.1% specificity in prediction of response to OT. Conclusions: We developed an imaging-based scoring system with good specificity that can be used as an adjunctive tool for patient counseling, and optimal selection of management options. Level of Evidence: 4 Laryngoscope, 131:E2243–E2250, 2021.
Databáze: OpenAIRE
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