Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels
| Autor: | Grw. Moore, Jasmine Gill, C. Laule, D. K. B. Li, Sophie Stukas, Virginia Devonshire, Jt. Yik, Pierre Becquart, Roger Tam, Rl. Carruthers, Alice Schabas, Anthony Traboulsee, Im. Vavasour, Sh. Kolind, Guojun Zhao, A-L. Sayao, Cl. Wellington, Ja. Quandt |
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| Rok vydání: | 2022 |
| Předmět: |
Pathology
medicine.medical_specialty Multiple Sclerosis Neurofilament Clinically isolated syndrome business.industry Neurofilament light Multiple sclerosis Intermediate Filaments Brain General Medicine medicine.disease Magnetic Resonance Imaging White Matter White matter Lesion load Multiple Sclerosis Relapsing-Remitting medicine.anatomical_structure Neurology Parenchyma Humans Medicine Neurology (clinical) Secondary progressive business |
| Zdroj: | Multiple Sclerosis and Related Disorders. 57:103422 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2021.103422 |
| Popis: | Summary We characterized the frequency of diffusely abnormal white matter (DAWM) across a broad spectrum of multiple sclerosis (MS) participants. 35% of clinically isolated syndrome (CIS), 57% of relapsing remitting and 64% of secondary progressive MS participants demonstrated DAWM. CIS with DAWM had decreased cortical thickness, higher lesion load and a higher concentration of serum neurofilament light chain compared to CIS without DAWM. DAWM may be useful in identifying CIS patients with greater injury to their brains. Larger and longitudinal studies are warranted. |
| Databáze: | OpenAIRE |
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