Natural killer/T-cell lymphoma and secondary haemophagocytic lymphohistiocytosis in pregnancy
| Autor: | Barbara Neistadt, A.R. Carrubba, Michael V Zaretksy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Gestational Age Lymphoma T-Cell Malignancy Lymphohistiocytosis Hemophagocytic 03 medical and health sciences Fatal Outcome 0302 clinical medicine Pregnancy Rare Disease hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Fetal distress Humans Medicine Treatment Failure 030219 obstetrics & reproductive medicine Cesarean Section business.industry Infant Newborn Respiratory infection General Medicine medicine.disease Pancytopenia 030220 oncology & carcinogenesis Etiology Natural Killer T-Cells Female Differential diagnosis business Pregnancy Complications Neoplastic Rare disease |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder. It is challenging to diagnose due to its rarity and variation in clinical presentation, laboratory abnormalities and underlying aetiologies. A reproductive-aged woman, gravida 2 para 1001 at 27 weeks gestation presented with fever, hypotension and subacute upper respiratory infection. She delivered a male infant by caesarean section secondary to fetal distress. Subsequently, she was diagnosed with T-cell lymphoma and secondary HLH. Despite management with supportive care and multiple chemotherapeutic agents, she ultimately died of multiorgan failure. Patients with HLH secondary to malignancy have a particularly poor prognosis. This case highlights the importance of considering secondary HLH in the differential diagnosis of a patient with fever, pancytopenia and systemic symptoms of unclear aetiology in pregnancy. |
| Databáze: | OpenAIRE |
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