Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS
| Autor: | Toshiji Saibara, Tsunehiro Ochi, Masafumi Ono, Takumi Kawaguchi, Masahiro Yamaguchi, Akira Hiramatsu, Takuji Torimura, Akira Hirose, Hiroshi Mizuta, Kosei Masuda, Shuhei Noguchi, Narufumi Suganuma, Takashi Nakahara, Kensuke Munekage, Kazuaki Chayama, Yuichi Koshiyama, Nobuto Okamoto, Mitsunari Ogasawara, Eisuke Murakami |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Serum albumin lcsh:Medicine Chronic liver disease Article 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Non-alcoholic Fatty Liver Disease Internal medicine Glucose Intolerance Nonalcoholic fatty liver disease Humans Medicine In patient lcsh:Science Serum Albumin Aged Multidisciplinary biology business.industry Continuous glucose monitoring lcsh:R Hepatitis C Chronic Middle Aged medicine.disease 030104 developmental biology Endocrinology biology.protein Female lcsh:Q 030211 gastroenterology & hepatology business Hepatic fibrosis |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-09256-4 |
| Popis: | Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). In the patients with NAFLD, Maximum blood glucose concentration and blood glucose swings were significantly correlated with hepatic fibrosis markers. In the patients with C-CH, however, those two CGMS parameters were negatively correlated with the serum albumin (ALB) concentration. Furthermore, in the patients with C-CH with an ALB concentration of ≤4.0 g/dl, those two CGMS parameters were negatively correlated with the ALB concentration with greater statistical significance. In conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified. In patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis. In those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia. |
| Databáze: | OpenAIRE |
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