The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas
| Autor: | D A Crooks, Nicholas D. Stafford, L T Condon, L Helboe, Stephen L. Atkin, M J C Rogers |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Acoustic neuroma Neuropeptide Biology Pathology and Forensic Medicine medicine otorhinolaryngologic diseases Somatostatin receptor 2 Humans Receptors Somatostatin Receptor Aged Somatostatin receptor General Medicine Original Articles Neuroma Acoustic Middle Aged medicine.disease Neoplasm Proteins Somatostatin biology.protein Immunohistochemistry Female sense organs Endothelium Vascular Schwann Cells Antibody |
| Popis: | Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in acoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition. |
| Databáze: | OpenAIRE |
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