Niche Inheritance: A Cooperative Pathway to Enhance Cancer Cell Fitness Through Ecosystem Engineering
| Autor: | Kimberline R. Yang, Donald S. Coffey, Kenneth J. Pienta, Steven M. Mooney, Russell S. Taichman, Jelani C. Zarif |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Process (engineering)
Cell Survival Niche Genetic Fitness dispersal filters Computational biology diaspora Biology Biochemistry tumor cell heterogeneity Genomic Instability 03 medical and health sciences Genetic Heterogeneity 0302 clinical medicine Neoplasms Tumor Microenvironment Prospects metastasis Humans Ecosystem Neoplasm Invasiveness Molecular Biology niche construction 030304 developmental biology 0303 health sciences Dispersion theory Ecology fungi Inheritance (genetic algorithm) food and beverages genetic instability Cell Biology Niche construction 030220 oncology & carcinogenesis Cancer cell |
| Zdroj: | Journal of Cellular Biochemistry |
| ISSN: | 1097-4644 0730-2312 |
| Popis: | Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering an ecosystem that promotes the genetic fitness of the species. Ecological dispersion theory can then be utilized to describe and model the steps and barriers involved in a successful diaspora as the cancer cells leave the original host organ and migrate to new host organs to successfully establish a new metastatic community. These ecological concepts can be further utilized to define new diagnostic and therapeutic areas for lethal cancers. 115: 1478–1485, 2014. © 2014 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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