Effects of various antidepressants on serum thyroid hormone levels in patients with major depressive disorder

Autor: Selçuk Kirli, Cengiz Akkaya, Aslı Sarandöl, Şengül Cangür, Emre Sarandol, Salih Saygin Eker
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Eker, Salih Saygın, Akkaya, Cengiz, Sarandol, Asli, Cangür, Şengül, Sarandol, Emre, Kırlı, Selçuk, ABE-1716-2020, Q-9477-2019
Rok vydání: 2008
Předmět:
Male
Refractory depression
Hyperthyroidism
Myxedema
Levothyroxine Sodium
Thyrotropin
Venlafaxine
Tricyclic antidepressants
Basal (phylogenetics)
Sertraline
Major depression
Pharmacology & Pharmacy
Psychiatric-patients
Psychiatry
Adrenergic Uptake Inhibitors
Depression
Reboxetine
Thyroid
Venlafaxine Hydrochloride
Middle Aged
Rat-brain
Antidepressive Agents
medicine.anatomical_structure
Clinical neurology
Triiodothyronine
Major depressive disorder
Female
Axis
Drug dose increase
Psychology
Drug mechanism
Free thyroxine index
Selective Serotonin Reuptake Inhibitors
Human
medicine.drug
Adult
Serotonin
Thyroid Hormones
endocrine system
medicine.medical_specialty
Adolescent
Morpholines
Desipramine treatment
Major clinical study
Neurosciences & neurology
Norepinephrine reuptake inhibitor
Article
Thyrotropin-releasing-hormone
Internal medicine
medicine
Humans
Serotonin uptake inhibitors
Biological Psychiatry
Aged
Psychiatric Status Rating Scales
Pharmacology
Depressive Disorder
Major
Neurosciences
Sex difference
Cyclohexanols
medicine.disease
Thyroid hormone
Drug effect
Thyroxine
Endocrinology
Reuptake inhibitor
Controlled study
Hormone
Zdroj: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:955-961
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2007.12.029
Popis: A total of 62 patients with major depressive disorder were analyzed in the study. Patients were evaluated for 11 weeks in an open label design to investigate the differential effects of reboxetine, sertraline and venlafaxine on thyroid hormones. Serum thyrotrophin (TSH), thyroxine (T4) and free (f)T4 levels were measured before and after treatment. All groups showed significant improvement in HAM-D scores. TSH level significantly reduced and T4 level significantly increased in the reboxetine group, however TSH level significantly increased and T4 level significantly reduced in the sertraline group. Percent changes of TSH (p=0.007) and T4 (p=0.001) were significantly different between the reboxetine and sertraline groups. In the sertraline group, baseline TSH levels were correlated with response to treatment as determined by the change in HAM-D scores (p=0.03, r=0.648). There was a significant association between the percent changes in TSH values and the reduction in HAM-D scores in the reboxetine group (p=0.03, r=-0.434). In the whole study group, female patients had lower values of basal T4 compared with men (P=0.043), however percent changes of T4 did not differ between genders. In the treatment-responders significant increase in the reboxetine group and significant decrease in the sertraline group regarding the T4 values were found. We observed that various antidepressants had different effects on thyroid hormone levels and this could be attributed to the different mechanisms of actions of these antidepressants.
Databáze: OpenAIRE
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