Central Metabotropic Glutamate Receptors Differentially Participate in Interleukin-1β–Induced Mechanical Allodynia in the Orofacial Area of Conscious Rats
| Autor: | Tae G. Kwon, Chang Y. Jung, Dong K. Ahn, Hyo S. Choi, Jin S. Ju, Hyo Sang Park, Yong C. Bae |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pain Threshold Agonist Sensory Receptor Cells medicine.drug_class Interleukin-1beta Group ii Glutamic Acid Pharmacology Receptors Metabotropic Glutamate Synaptic Transmission Mechanical Allodynia Rats Sprague-Dawley Subcutaneous injection Facial Pain mental disorders Excitatory Amino Acid Agonists Reaction Time medicine Animals Afferent Pathways business.industry musculoskeletal neural and ocular physiology Antagonist Nociceptors Rats nervous system diseases Interleukin 1β Disease Models Animal Anesthesiology and Pain Medicine nervous system Neurology Hyperalgesia Metabotropic glutamate receptor Vibrissae Metabotropic glutamate receptor 1 Neurology (clinical) business Excitatory Amino Acid Antagonists Neuroscience |
| Zdroj: | The Journal of Pain. 7:747-756 |
| ISSN: | 1526-5900 |
| Popis: | The present study investigated the role of central metabotropic glutamate receptors (mGluRs) in interleukin-1β (IL-1β)–induced mechanical allodynia and mirror-image mechanical allodynia in the orofacial area. Experiments were carried out on male Sprague-Dawley rats weighing 230 to 280 g. After administration of 0.01, 0.1, 1, or 10 pg of IL-1β into a subcutaneous area of the vibrissa pad, we examined the withdrawal behavioral responses produced by 10 successive trials of an air-puff ramp pressure applied ipsilaterally or contralaterally to the IL-1β injection site. Subcutaneous injection of IL-1β produced mechanical allodynia and mirror-image mechanical allodynia in the orofacial area. Intracisternal administration of CPCCOEt, a mGluR1 antagonist, or MPEP, a mGluR5 antagonist, reduced IL-1β–induced mechanical allodynia and mirror-image mechanical allodynia. Intracisternal administration of APDC, a group II mGluR agonist, or L-AP4, a group III mGluR agonist, reduced both IL-1β–induced mechanical allodynia and mirror-image mechanical allodynia. The antiallodynic effect, induced by APDC or L-AP4, was blocked by intracisternal pretreatment with LY341495, a group II mGluR antagonist, or CPPG, a group III mGluR antagonist. These results suggest that groups I, II, and III mGluRs differentially modulated IL-1β–induced mechanical allodynia, as well as mirror-image mechanical allodynia, in the orofacial area. Perspective Central group I mGluR antagonists and groups II and III mGluR agonists modulate IL-1β–induced mechanical allodynia and mirror-image mechanical allodynia in the orofacial area. Therefore, the central application of group I mGluR antagonists or groups II and III mGluR agonists might be of therapeutic value in treating pain disorder. |
| Databáze: | OpenAIRE |
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