Nanodispersion-loaded mucoadhesive polymeric inserts for prolonged treatment of post-operative ocular inflammation

Autor: Hanan Refai, Nadia M. Morsi, Dalia Ghorab, Hoda Teba
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Materials science
genetic structures
Pharmaceutical Science
Bioengineering
02 engineering and technology
Eye
030226 pharmacology & pharmacy
Ketorolac Tromethamine
Chitosan
03 medical and health sciences
Entrapment
chemistry.chemical_compound
Drug Delivery Systems
Postoperative Complications
0302 clinical medicine
Colloid and Surface Chemistry
Polyphosphates
Cornea
Zeta potential
medicine
Animals
Particle Size
Physical and Theoretical Chemistry
Ocular inflammation
Inflammation
Aqueous solution
Organic Chemistry
technology
industry
and agriculture
Permeation
021001 nanoscience & nanotechnology
eye diseases
Surgery
medicine.anatomical_structure
chemistry
Nanoparticles
Cattle
Rabbits
sense organs
Particle size
Ophthalmic Solutions
0210 nano-technology
Biomedical engineering
Zdroj: Journal of Microencapsulation. 34:280-292
ISSN: 1464-5246
0265-2048
DOI: 10.1080/02652048.2017.1321048
Popis: Mucoadhesive polymeric films incorporated with ketorolac tromethamine-loaded nanodispersion aiming the sustained delivery of the drug to the cornea have been developed and characterised for the treatment of post-operative ocular inflammation. Nanodispersions were prepared by ionic gelation method with various concentrations of chitosan and sodium tripolyphosphate. The developed nanodispersions were analysed for morphology, particle size, dispersion homogeneity, zeta potential, entrapment efficiency and drug release. The nanodispersion that showed the smallest particle size and the highest entrapment efficiency was incorporated in optimised HPMC E15 and Eudragit RL100/HPMC K4m films. The formulation with optimum physicomechanical properties was selected to study its ex vivo transcorneal permeation through freshly excised bovine cornea in comparison with the nanodispersion and the marketed eye drops (Acular®). The polymeric ocular film showed greater permeation than aqueous eye drops. Moreover, the ocular film revealed a prolonged anti-inflammatory effect compared to eye drops when applied to inflamed rabbit's eyes.
Databáze: OpenAIRE
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